Cardiovascular Biology of the Incretin System
نویسندگان
چکیده
منابع مشابه
Cardiovascular biology of the incretin system.
Glucagon-like peptide-1 (GLP-1) is an incretin hormone that enhances glucose-stimulated insulin secretion and exerts direct and indirect actions on the cardiovascular system. GLP-1 and its related incretin hormone, glucose-dependent insulinotropic polypeptide, are rapidly inactivated by the enzyme dipeptidyl peptidase 4 (DPP-4), a key determinant of incretin bioactivity. Two classes of medicati...
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Cardiovascular disease (CVD), a leading cause of death in patients with diabetes mellitus, has several pathogenic mechanisms that are well established. However, the traditional hypoglycemic agents do not have proven positive effects on macrovascular disease. Novel therapeutic agents target the incretin pathway including the glucagon-like peptide 1 (GLP-1) receptor (GLP-1R) agonists and the dipe...
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ژورنال
عنوان ژورنال: Endocrine Reviews
سال: 2012
ISSN: 0163-769X,1945-7189
DOI: 10.1210/er.2011-1052